Description
A pyrimidone that is thymine which is substituted at positions 1 and 6 by a (2-hydroxyethoxy)methyl group and a phenylsulfanyl group, respectively.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C14H16N2O4S | 0 | 308.35300 |
![1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine](images/1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine.svg)
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 1-[(2-hydroxyethoxy)methyl]-5-methyl-6-(phenylsulfanyl)pyrimidine-2,4(1H,3H)-dione | Cc1c(Sc2ccccc2)n(COCCO)c(=O)[nH]c1=O | InChI=1S/C14H16N2O4S/c1-10-12(18)15-14(19)16(9-20-8-7-17)13(10)21-11-5-3-2-4-6-11/h2-6,17H,7-9H2,1H3,(H,15,18,19) | HDMHBHNRWDNNCD-UHFFFAOYSA-N |
|
Citations
- De Clercq, E, et al. 2006. Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future. Chemistry & Biodiversity. 1(1).
- Ito, M, et al. 1991. Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT) and recombinant alpha interferon. Antiviral Research. 15(4).
- Tanaka, H, et al. 1991. A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Journal of Medicinal Chemistry. 34(1).